Synthesis of ara-Cadeguomycin. 2-Amino-3,4-dihydro-4-oxo-7-(β-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic Acid
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چکیده
منابع مشابه
Pyrrolopyrimidine Nucleosides 19.1 a Total Synthesis of the Nucleoside Antibiotic Cadeguomycin [z-amino-7-(b-d-ribofuranosyl)- Pyrrolo[2,3-~]pyrimidin-4-one-5-carboxylic Acid]
Vladimir G. Beylin, Andrew M. Kawasaki, Chin Shu Cheng, and Leroy B. Townsend* Department of Medicinal Chemistry, College of Pharmacy, and Department of Chemistry University of Michigan, Ann Arbor, Michigan 48109 Abstract. A total synthesis of 2-amino-7-(O-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidin-4-one5-carboxylic acid has been accomplished and confirms the previous structural assignment for the...
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Accurate ab initio calculations at the B3LYP/6-311 G** level have been performed on anionic and neutral structures of 4,5-dihydro-5-oxo[1,2,4]triazolo[1,5-a]pyrimidine, 4,7-dihydro-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine, and 4,5-dihydro-7-amino-5-oxo[1,2,4]triazolo[1,5-a]pyrimidine compounds. The quality of the theoretical results has been tested against the experimental X-ray structures for the...
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In the title herbicideh/phytocide, known as imaza-pic, C(14)H(17)N(3)O(3), the pyridine and imidazole rings are almost coplanar [dihedral angle = 3.08 (5)°]. An intra-molecular O-H⋯N hydrogen bond occurs. In the crystal, an N-H⋯O hydrogen bond links mol-ecules into a chain parallel to [010].
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1986
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.59.1915